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Ipamorelin is the cleanest growth hormone secretagogue available for research. It activates the ghrelin receptor (GHSR-1a) to trigger pulsatile GH release from the pituitary — without the cortisol, prolactin, or ACTH elevation that made earlier GHRPs problematic. If you're researching GH axis activation without off-target hormone interference, ipamorelin is the benchmark. True North Peptides supplies ipamorelin at ≥99% purity in 10mg lyophilised vials. For research use only.
Ipamorelin is a third-generation growth hormone secretagogue — a synthetic pentapeptide that activates the GHSR-1a (ghrelin receptor) at the pituitary to stimulate GH release. It was specifically designed to solve a problem with earlier GHRPs: they worked for GH release, but they also raised cortisol, prolactin, and ACTH. Ipamorelin was engineered to separate the GH stimulus from those off-target effects — and it succeeded. At effective research concentrations, cortisol and prolactin elevations are negligible.
Pulsatile GH — Why It Matters
Your pituitary naturally releases GH in pulses — not as a continuous stream. This pulsatile pattern is important because the downstream effects of GH on IGF-1, body composition, and cellular repair are regulated by this rhythm. Direct GH administration (somatropin) gives you a sustained, non-pulsatile GH profile. Ipamorelin triggers GH release in a pattern that closely mimics natural pulsatile secretion — which is why it's a preferred tool for studying the GH axis in its natural physiological context.
Ipamorelin vs Tesamorelin
Both stimulate pituitary GH release, but through different receptors. Ipamorelin acts on GHSR-1a (the ghrelin receptor). Tesamorelin acts on GHRHR (the GHRH receptor). They're the two most common GH secretagogue research tools, and many advanced protocols run them together — stimulating both GH release pathways simultaneously for a more complete GH axis investigation.
Storage & Handling
Store lyophilised ipamorelin at −20°C. Reconstitute with bacteriostatic water, gentle swirling. Refrigerate at 2–8°C post-reconstitution, use within 4–6 weeks.
Product Specifications
Peptide: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ | CAS: 170851-70-4 | Molecular Weight: 711.85 g/mol | Form: Lyophilised powder | Vial Size: 10mg | Purity: ≥99% | Storage: −20°C dry; 2–8°C post-reconstitution.
Store lyophilised product at -20°C or below. After reconstitution, store at 4°C and use within 30 days. Keep away from direct sunlight and moisture.
This product is intended for laboratory and research use only. Not for human or veterinary use. Must be handled by qualified researchers in an appropriate facility.
