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NAD+ is the coenzyme that powers your mitochondria, activates your longevity genes (sirtuins), and fuels DNA repair. The problem: it declines by roughly 50% between your 20s and 60s, and that decline tracks closely with the hallmarks of ageing. If you're researching cellular energy, sirtuin biology, or anti-ageing mechanisms, NAD+ is the central variable. True North Peptides supplies research-grade NAD+ at 500mg per vial. For research use only.
What Is NAD+?
NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme present in every single cell in your body — and it's one of the most important molecules in biology. It's the electron carrier that drives the mitochondrial electron transport chain (where most of your cellular energy is made). It's the substrate that sirtuins — your longevity-regulating genes — require to function. And it's what PARP enzymes consume to repair broken DNA. The decline of NAD+ with age is now considered a central driver of the ageing process across multiple research frameworks.
Sirtuins — Your Longevity Switch
SIRT1 through SIRT7 are the sirtuin family — NAD+-dependent enzymes that regulate mitochondrial biogenesis, inflammation, circadian rhythm, and cellular stress response. They can't function without NAD+. When NAD+ drops with age, sirtuin activity drops with it. Research into NAD+ repletion is largely about restoring the fuel that keeps these longevity-regulating enzymes operational.
NAD+ vs NMN vs NR — What's The Difference?
NMN and NR are precursors — your cells convert them to NAD+ through enzymatic pathways. NAD+ is the end product. For research designs where you want to control exactly how much NAD+ is available at the cellular level — without the variable of precursor conversion efficiency — using NAD+ directly eliminates a confounding step. Both approaches are studied; the right choice depends on your research question.
Storage & Handling
NAD+ is sensitive to light and moisture. Store lyophilised NAD+ at −20°C in a sealed, light-protected container. Use reconstituted solutions promptly. Do not subject to freeze-thaw cycles.
Product Specifications
Compound: Nicotinamide Adenine Dinucleotide (NAD+) | CAS: 53-84-9 | Molecular Weight: 663.43 g/mol | Form: Lyophilised powder | Vial Size: 500mg | Purity: Research-grade | Storage: −20°C dry, protect from light.
Store lyophilised product at -20°C or below. After reconstitution, store at 4°C and use within 30 days. Keep away from direct sunlight and moisture.
This product is intended for laboratory and research use only. Not for human or veterinary use. Must be handled by qualified researchers in an appropriate facility.
